Here we present the initial investigation on microfabrication of DNA sensor based on electrical detection. We introduced a novel material on detecting DNA hybridization event using polymer-carbon nanotubes (polymer-CNT) composite as the electrode. Moreover, we did a proof of concept on the functionality of the electrodes which covers the material design and micro-fabrication trial. As a first approach, we tested the polymer-CNT film to sense cell adhesion by monitoring its impedance changing.