The very high heat flux dissipated by a Central Processing Unit (CPU) can no longer be handled by a conventional, single-phased cooling system. Thermal management of a CPU is now moving towards two-phase systems to maintain CPUs below their maximum temperature. A heat pipe is one of the emerging cooling systems to address this issue because of its superior efficiency and energy input independence. The goal of this research is to improve the performance of a heat pipe by integrating a biomaterial as the wick structure. In this work, the heat pipe was made from copper pipe and the biomaterial wick structure was made from tabulate coral with a mean pore diameter of 52.95 μm. For comparison purposes, the wick structure was fabricated from sintered Cu-powder with a mean pore diameter of 58.57 µm. The working fluid for this experiment was water. The experiment was conducted using a processor as the heat source and a plate simulator to measure the heat flux. The utilization of coral as the wick structure can improve the performance of a heat pipe and can decrease the temperature of a simulator plate by as much as 38.6 % at the maximum heat load compared to a conventional copper heat sink. This method also decreased the temperature of the simulator plate by as much as 44.25 °C compared to a heat pipe composed of a sintered Cu-powder wick.